{"id":19594,"date":"2025-04-14T18:32:31","date_gmt":"2025-04-14T18:32:31","guid":{"rendered":"https:\/\/mpower.maryland.edu\/?p=19594"},"modified":"2025-04-17T12:54:33","modified_gmt":"2025-04-17T12:54:33","slug":"mpower-initiative-kicks-off-first-of-its-kind-collaboration-between-engineering-and-medical-schools","status":"publish","type":"post","link":"https:\/\/mpower.maryland.edu\/mpower-initiative-kicks-off-first-of-its-kind-collaboration-between-engineering-and-medical-schools\/","title":{"rendered":"University of Maryland Researchers Will Test Cutting-Edge Microscope To Explore Causes of Glaucoma"},"content":{"rendered":"\n<p><sub>University of Maryland bioengineering researcher Giuliano Scarcelli develops microscopes for studying diseases of the eye that rely on Brillouin microscopy, which can measures the stiffness of tissues and cells without touching the eye. Photo credit: John T. Consoli.<\/sub><\/p>\n\n\n\n<div style=\"height:34px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Published in <a href=\"https:\/\/today.umd.edu\/to-explore-causes-of-glaucoma-umcp-umb-researchers-will-test-cutting-edge-microscope\">Maryland Today<\/a><\/strong> | <strong>April 14, 2025<\/strong><\/p>\n\n\n\n<div style=\"height:31px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Glaucoma is a progressive, irreversible disease\u2014the second-leading cause of blindness worldwide. It affects about 3 million Americans, yet half don\u2019t know they have it until they start losing their sight.<\/p>\n\n\n\n<p><strong><a href=\"https:\/\/bioe.umd.edu\/clark\/faculty\/199\/Giuliano-Scarcelli\">Giuliano Scarcelli<\/a><\/strong>, a University of Maryland associate professor of bioengineering, has spent his 20-year career building novel microscopes that detect early stages of corneal disease, helping patients ward off the need for surgery or even transplant. Now he is using his technology to explore the causes of glaucoma, hoping to spur development of new treatments. This month he is debuting his newest microscope, which will be tested with patients being treated at the <strong><a href=\"http:\/\/medschool.umaryland.edu\">University of Maryland School of Medicine<\/a><\/strong> (<strong>UMSOM<\/strong>).<\/p>\n\n\n\n<p>Scarcelli is one of two inaugural co-directors of the new <strong>Edward &amp; Jennifer St. John Center for Translational Engineering and Medicine<\/strong>,&nbsp;<a href=\"https:\/\/today.umd.edu\/edward-and-jennifer-st-john-give-10m-for-new-center-for-translational-engineering-and-medicine\"><strong>an initiative fostering face-to-face partnerships<\/strong><\/a>&nbsp;among researchers at the <strong><a href=\"http:\/\/umaryland.edu\">University of Maryland, Baltimore<\/a><\/strong> (<strong>UMB<\/strong>), which houses UMSOM, and the <strong><a href=\"https:\/\/eng.umd.edu\/\">A. James Clark School of Engineering<\/a><\/strong> at the <strong><a href=\"http:\/\/umd.edu\">University of Maryland, College Park<\/a><\/strong> (<strong>UMCP<\/strong>). The center, announced in January, is funded with a $10 million gift from the St. Johns and the Edward St. John Foundation,&nbsp;<a href=\"https:\/\/today.umd.edu\/12-75m-mpower-grant-to-spur-biomedical-tech-advances-in-umcp-umb-collaboration\"><strong>along with a $12.75 million grant<\/strong><\/a>&nbsp;from the&nbsp;<a href=\"https:\/\/mpower.maryland.edu\/\"><strong>University of Maryland Strategic Partnership: <\/strong><\/a><em><a href=\"https:\/\/mpower.maryland.edu\/\"><strong>MPowering the State<\/strong><\/a>.<\/em><\/p>\n\n\n\n<p>Scarcelli\u2019s microscopes rely on Brillouin microscopy, a light-scattering technique that measures the stiffness of tissues and cells without touching the body\u2014in this case the eye. The device can detect the tiniest natural vibrations within an eye\u2019s tissue, providing information about its mechanical properties.<\/p>\n\n\n\n<p>Unlike corneal disease, which manifests in the front of the eye, glaucoma patients suffer damage to the optic nerve, which is the nerve that connects each eye to the brain. Though elevated pressure is a common driver, the range of causes isn\u2019t known. Unveiled last month, Scarcelli\u2019s newest microscope is designed to determine eye stiffness, which might be a contributing factor.<\/p>\n\n\n\n<p>\u201cIt\u2019s expected that the pressure readings in a glaucoma patient are highly affected by how soft their cornea is,\u201d Scarcelli said, likening an eye to an air balloon: If it\u2019s softer in one area, it\u2019s easier to push on it, regardless of its internal pressure.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/mpower.maryland.edu\/wp-content\/uploads\/2025\/04\/3C5A0439_1920x1080-In-article-image.png\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/mpower.maryland.edu\/wp-content\/uploads\/2025\/04\/3C5A0439_1920x1080-In-article-image.png\" alt=\"\" class=\"wp-image-19604\"\/><\/a><\/figure>\n\n\n\n<p><sub>Dr. Osamah J. Saeedi (right) examines a patient&#8217;s eye at the Edward &amp; Jennifer St. John Center for Translational Engineering and Medicine, where he and UMD bioengineering researcher Giuliano Scarcelli (center) are co-directors. Photo Credit: John T. Consoli.<\/sub><\/p>\n\n\n\n<div style=\"height:28px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Dr. Osamah J. Saeedi, an expert in the disease and professor of ophthalmology and visual sciences at UMSOM\u2014who joins Scarcelli as co-director of the St. John Center for Translational Engineering and Medicine\u2014is betting that the new microscope can successfully be applied to his patients, some of whom don\u2019t exhibit high eye pressure at all.<\/p>\n\n\n\n<p>\u201cFor glaucoma, there\u2019s been a real need to determine the basic biomechanics of the eye,\u201d he said. \u201cWe want to find a way to do it noninvasively, and with Giuliano\u2019s technique there is vast potential.\u201d<\/p>\n\n\n\n<p>Supported by a&nbsp;<a href=\"https:\/\/reporter.nih.gov\/search\/UrHFsoMwCEKhJGAKhvThWg\/project-details\/10888544\"><strong>National Institutes of Health grant<\/strong><\/a>, Saeedi aims to identify once-elusive biomarkers of glaucoma among his patients, identify risks and develop personalized treatments by exploring mechanical variations within the eye.<\/p>\n\n\n\n<p>Scarcelli built his first microscopes in 2006 as a postdoctoral fellow at Harvard Medical School, supplying them to Boston\u2019s Massachusetts General Hospital to identify corneal diseases at early stages, before joining the UMD faculty in 2015.<\/p>\n\n\n\n<p>Until recently, measuring an eye\u2019s biomechanics has required applying force on the cornea, which inherently biases the measurement. Scarcelli\u2019s contactless device eliminates this issue.<\/p>\n\n\n\n<p>This summer, Scarcelli will take on a different kind of challenge: using Brillouin microscopy in Baltimore to measure biomechanics beyond the eye, an endeavor he&nbsp;<a href=\"https:\/\/www.nature.com\/articles\/s43586-023-00286-z\"><strong>outlined in a paper published<\/strong><\/a>&nbsp;last year in&nbsp;<em>Nature Reviews<\/em>. In his new lab at UMB, he will attempt to measure the stiffness of everything from blood to cancer cells to better understand the disease\u2019s progression. The lab will be staffed with several postdoctoral fellows and doctoral students.<\/p>\n\n\n\n<p>The Center for Translational Engineering and Medicine occupies the entire fourth floor of 4MLK, a new state-of-the-art facility in the University of Maryland BioPark. From his post, Scarcelli is already in discussions with other UMSOM eye doctors about developing new microscopes for more diseases like retinal failure.<\/p>\n\n\n\n<p>\u201cWe need to meet face to face with clinicians to drive the technology forward,\u201d Scarcelli said. \u201cExploratory projects and preliminary data are born this way.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Clinical Initiative Kicks Off First-of-Its-Kind Collaboration Between Engineering and Medical Schools<\/p>\n","protected":false},"author":160,"featured_media":19597,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[196,11,20,1],"tags":[],"class_list":["post-19594","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-home","category-in-the-press","category-news","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>University of Maryland Researchers Will Test Cutting-Edge Microscope To Explore Causes of Glaucoma - MPower Maryland<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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