{"id":19232,"date":"2025-02-26T21:41:27","date_gmt":"2025-02-26T21:41:27","guid":{"rendered":"https:\/\/mpower.maryland.edu\/?p=19232"},"modified":"2025-03-04T17:17:49","modified_gmt":"2025-03-04T17:17:49","slug":"three-bioe-students-receive-2024-2025-mpower-graduate-fellowships","status":"publish","type":"post","link":"https:\/\/mpower.maryland.edu\/three-bioe-students-receive-2024-2025-mpower-graduate-fellowships\/","title":{"rendered":"Three BIOE Students Receive 2024-2025 MPower Graduate Fellowships"},"content":{"rendered":"\n

Published by Fischell Department of Bioengineering<\/a> | February 17, 2025<\/strong><\/p>\n\n\n\n

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The University of Maryland, College Park\u2019s (UMCP)<\/a><\/strong> Fischell Department of Bioengineering<\/a> (BIOE)<\/strong> and the Schools of Dentistry<\/strong><\/a>, Medicine<\/strong><\/a>, and Pharmacy<\/strong><\/a> at University of Maryland, Baltimore (UMB)<\/a><\/strong> awarded the 2024-2025 MPower <\/em>Graduate Fellowship to three BIOE Ph.D. students: Kathleen Trang<\/strong>, Rohey Colley<\/strong>, and Tianfeng Miao<\/strong>. Through this fellowship, the recipients will engage in joint research projects as part of a collaborative Ph.D. program with both universities, offering an opportunity to develop and provide technical solutions for pressing clinical challenges in medicine, pharmacy, or dentistry.<\/p>\n\n\n\n

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Kathleen Trang<\/strong> is a first-year Ph.D. student in Assistant Professor Alex Xu<\/strong>\u2019s Spatial Biology Lab<\/strong><\/a>, where she studies the spatial relationships between cells and extracellular components to better understand disease mechanisms. Using tissue microarrays, her team applies fluorescent staining to visualize up to 40 different proteins simultaneously, generating large-scale, information-rich images. These images inform a machine learning algorithm to identify potential therapeutic targets.<\/p>\n\n\n\n

Trang was drawn to UMCP for its strong ties to government research institutions and its highly collaborative environment. As a computational bioengineer, she values the ability to bridge the gap between data-driven research and clinical applications.<\/p>\n\n\n\n

One of her most significant research accomplishments came during her time at the University of Florida, where she published a method to improve accessibility in single-cell migration assay analysis<\/strong><\/a>. This milestone reinforced her interest in computational image processing and machine learning\u2019s role in advancing bioengineering research.<\/p>\n<\/div><\/div>\n\n\n\n

As an MPower <\/em>Fellow, Trang is excited to apply her computational expertise in a clinical setting for the first time. Working alongside Associate Professor of Obstetrics, Gynecology, and Reproductive Sciences at UMB, Dr. Dana Roque<\/strong><\/a>, she aims to expand her team\u2019s analysis methods beyond cellular structures to include extracellular components, furthering the understanding of the ovarian cancer tumor microenvironment. Her research will also employ machine learning to explore how different protein expression levels influence immune infiltration, potentially leading to new therapeutic approaches.<\/p>\n\n\n\n

\u201cI\u2019m incredibly grateful to have been awarded the MPower <\/em>Fellowship,\u201d Trang says. \u201cThis opportunity allows me to translate computational methods into tangible clinical insights. In the future I hope that my research can be applied to a broad range of diseases beyond ovarian cancer.\u201d<\/p>\n\n\n\n

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Rohey Colley<\/strong> is a first-year Ph.D. student in Assistant Professor Erika Moore<\/strong>\u2019s Lab<\/strong><\/a>. Colley’s research focuses on immune engineering, particularly the role of macrophages in tissue repair, regeneration, and disease progression. She investigates how macrophages respond to mechanical and biochemical cues within 3D biomaterial environments, which has significant implications for understanding inflammatory diseases and fibrosis.<\/p>\n\n\n\n

One of the most significant moments in Colley\u2019s research career was conducting her capstone project on pulmonary embolism, a condition that nearly took her mother\u2019s life after her younger brother\u2019s birth. This personal connection reinforced her passion for improving medical outcomes. Her project focused on developing an AI-driven method for volumetric assessment of pulmonary artery thrombus burden, addressing a major public health concern.<\/p>\n<\/div><\/div>\n\n\n\n

Colley was drawn to UMCP due to the breadth of expertise within the department and its highly collaborative and accessible research environment. \u201cThe department\u2019s layout fosters interdisciplinary interaction, eliminating barriers to communication and making it easy to engage with researchers across different specialties,\u201d Colley says.<\/p>\n\n\n\n

As an MPower <\/em>Fellow, Colley will work on a project investigating macrophage responses to mechanical and biochemical cues within 3D biomaterial models. Through her collaboration with the Director of Molecular Medicine and Professor of Physiology at UMB, Dr. Toni Antalis<\/strong><\/a>, she will extend her research to explore macrophage interactions in disease-relevant contexts, particularly inflammatory and thrombotic diseases. She aims to integrate biomaterial engineering with immune profiling to advance the understanding of fibrosis and tissue remodeling.<\/p>\n\n\n\n

\u201cI am incredibly honored and grateful to be a recipient of the MPower Graduate Fellowship,\u201d Colley says. \u201cThis award allows me to bridge bioengineering and clinical research, working collaboratively between UMCP and UMB to drive impactful discoveries.\u201d<\/p>\n\n\n\n

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“The department\u2019s layout fosters interdisciplinary interaction, eliminating barriers to communication and making it easy to engage with researchers across different specialties.”<\/h3>\n\n\n\n

-Rohey Colley<\/p>\n<\/blockquote>\n\n\n\n

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Tianfeng Miao<\/strong> is a first-year Ph.D. student in Assistant Professor Alex Xu<\/strong>\u2019s Spatial Biology Lab<\/strong><\/a>. Miao\u2019s research focuses on applying spatial omics and computational tools to analyze tissue samples, aiming to unravel disease mechanisms and improve treatment strategies. He currently focuses on spatially resolving heart xenograft tissue, which can provide insights for improving xenograft transplantation.<\/p>\n\n\n\n

\u201cI\u2019ve learned about the mutually beneficial mentoring connections and collaborative projects, and I believe being a part of such a supportive environment will help me grow both academically and personally,\u201d Miao says.<\/p>\n<\/div><\/div>\n\n\n\n

Miao was drawn to UMCP because of its strong sense of community and the opportunities it offers. During his master\u2019s, Miao presented his research at the Annual Meeting of the Orthopaedic Research Society, where he shared his work with scholars from around the world.<\/p>\n\n\n\n

The MPower <\/em>Fellowship offers Miao the opportunity to collaborate with the Director of the Cardiac Xenotransplantation Program at UMB, Dr. Muhammad Mohiuddin<\/strong><\/a>. Their joint project aims to leverage the strengths of spatial omics to analyze rare heart xenograft tissue from a unique perspective. Miao hopes to untangle the complex mechanisms of xenograft failure to further extend its longevity.<\/p>\n\n\n\n

\u201cI am very excited to receive the MPower Graduate Fellowship and deeply appreciate the collaborative opportunity it offers,\u201d Miao says. \u201cTogether, our research will advance the clinical value of heart xenografts.\u201d<\/p>\n\n\n\n

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