{"id":17789,"date":"2024-09-25T17:18:05","date_gmt":"2024-09-25T17:18:05","guid":{"rendered":"https:\/\/mpower.maryland.edu\/?p=17789"},"modified":"2025-01-08T19:55:35","modified_gmt":"2025-01-08T19:55:35","slug":"fzata-inc-announces-multi-million-dollar-nih-grant","status":"publish","type":"post","link":"https:\/\/mpower.maryland.edu\/fzata-inc-announces-multi-million-dollar-nih-grant\/","title":{"rendered":"Fzata, Inc. Announces Multi-Million Dollar NIH Grant"},"content":{"rendered":"\n<p><strong>Published in <a href=\"https:\/\/www.prnewswire.com\/news-releases\/fzata-inc-announces-multi-million-dollar-nih-grant-302255849.html?tc\">PR Newswire<\/a>  |  September 24, 2024<\/strong><\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Fzata, Inc. is pleased to announce a five-year UG3\/UH3 non-dilutive grant (UG3NS135350) of up to&nbsp;$7 million, plus in-kind contributions, awarded by the <strong>NIH National Institute of Neurological Disorders and Stroke (NINDS)<\/strong>. Grant participants include <strong><a href=\"https:\/\/www.fzata.com\/#:~:text=Fzata,%20Inc.%20is%20a%20preclinical%20oral%20biologics%20therapeutics%20company.%20Fzata's\">Fzata <\/a><\/strong>and the&nbsp;<strong><a href=\"https:\/\/www.umaryland.edu\/\">University of Maryland, Baltimore&nbsp;(UMB)<\/a><\/strong>. The grant supports development of BioPYM\u2122 drug candidate FZ006 as a safe and effective oral treatment for chronic visceral pain associated with inflammatory bowel syndrome (IBS). Work under the grant will include IND-enabling studies, GLP toxicology, cGMP manufacturing, phase 1 trial design, IND submission, and Phase 1a clinical trial.<\/p>\n\n\n\n<p>Dr.&nbsp;Zhiyong Yang, President and CEO of Fzata, commented, &#8220;Chronic visceral pain associated with IBS is a serious unmet need. Ten to 15 percent of Americans suffer with severe pain, but treatment options are often inadequate. The most effective opioid treatments come with a high risk of addiction, a national problem. FZ006 will be the first effective, safe, non-addictive option to treat chronic abdominal pain. We are excited to work with the outstanding team we assembled, including labs at UMB and NINDS, to bring a real game-changer to IBS patients and their families.&#8221;<\/p>\n\n\n\n<p>&#8220;This NIH award presents a wonderful opportunity for Fzata, one of UMB&#8217;s startup portfolio companies, to advance development of their platform technology for an important medical need. It&#8217;s gratifying that the funded work will be in collaboration with UMB scientists,&#8221; said&nbsp;Phil Robilotto, DO, MBA, associate vice president of technology transfer at UMB and director of <strong><a href=\"https:\/\/www.umventures.org\/#:~:text=UM%20Ventures%20is%20a%20joint%20initiative%20of%20the%20University%20of\">UM Ventures,&nbsp;Baltimore<\/a><\/strong>. &#8220;We are excited by Fzata&#8217;s continued pipeline advancements, including (&#8220;FZ002&#8221;) for&nbsp;<em>C. difficile<\/em>&nbsp;infections, which is based on technology licensed from UMB and expected to start first-in-human clinical trials in 2025.&#8221;<\/p>\n\n\n\n<div style=\"height:22px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">About Fzata, Inc.<\/h3>\n\n\n\n<p>The Company has innovated and developed a next-generation therapeutics platform called <strong>Bioengineered Probiotic Yeast Medicines (BioPYM\u2122) <\/strong>for oral live biotherapeutics. BioPYM enables probiotic yeast to function as a micro-factory within the gut, producing therapeutics on site where disease pathologies occur. The &#8220;plug and play&#8221; platform accepts any gene to make biotherapeutic proteins including monoclonal antibodies, enzymes, cytokines,&nbsp;and hormones. Leveraging BioPYM, the Company has a pipeline of proprietary drug candidates to treat a wide variety of gastrointestinal diseases and gut-health axis disorders.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Five-year grant to UMB startup supports development of drug for treating IBS<\/p>\n","protected":false},"author":160,"featured_media":17790,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[196,1],"tags":[],"class_list":["post-17789","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-home","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Fzata, Inc. 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